I-3-C AOR NPN 80023077

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Indole-3-carbinol (I-3-C) is a phytonutrient found in Brassica vegetables such as broccoli, kale and cabbage, and is one of the key health-promoting compounds in these foods. Many studies have had phenomenal success using I-3-C to shift the balance of metabolic enzymes that process estrogens thereby reducing the formation of “bad” estrogens and increasing the formation of “good” estrogens. Human studies in women taking I-3-C have shown a favourable shift in estrogen metabolism, and I-3-C has been shown to be protective against estrogen dominance. Estrogen dominance has been linked to fibroids, breast tenderness, premenstrual syndrome, endometriosis and other women’s health concerns.

Women who are concerned with safer estrogen metabolism, who have a family history or increased risk of estrogen-dependent cancers, or those that have a higher ratio of bad to good estrogens can benefit from this product. I-3-C may also be a beneficial supplement for those who want to reap some of the benefits of Brassica vegetables but have difficulty eating them raw.

AOR Advantage

AOR’s I-3-C provides a safe and effective dose of this natural ingredient.


Label Information 




I-3-C helps to promote healthy estrogen metabolism and balance.


AOR™ guarantees that all ingredients have been declared on the label. Contains no wheat, gluten, corn, nuts, peanuts, sesame seeds, sulphites, mustard, soy, dairy, eggs, fish, shellfish or any animal byproduct.

Adult Dosage

Take one capsule one to two times daily with or without food, or as directed by a qualified health care practitioner.


Consult a health care practitioner prior to use to exclude the diagnosis of a serious cause of hormonal imbalance, if you are taking any medications or natural health products, if you are attempting to conceive, if you have a liver disorder, or symptoms of low estrogen (such as joint pain, mood changes, changes in libido, hot flashes, night sweats, vaginal dryness or irregular menstruations). Discontinue use and consult a health care practitioner if you develop liver-related symptoms (e.g., abdominal pain, jaundice) or symptoms of low estrogen. Do not use if you are pregnant or breastfeeding.

Main Applications

  • Estrogen metabolism
  • Women’s health


The information and product descriptions appearing on this website are for information purposes only, and are not intended to provide or replace medical advice to individuals from a qualified health care professional. Consult with your physician if you have any health concerns, and before initiating any new diet, exercise, supplement, or other lifestyle changes.

Supplement FactsServing Size: One Capsule

Indole-3-Carbinol (I3C)
200 mg

Non-medicinal Ingredients: microcrystalline cellulose.

Capsule: hypromellose.

Research Facts

Human Research

Knowing the role of “bad” estrogen in women’s health and I3C’s ability to change estradiol metabolism from “bad” to “good,” a series of experiments have been conducted using I3C. Favorable results ultimately led up to a prospective, randomized, double-blind, placebo-controlled trial of I3C in women.

Dr. Bell and her colleagues from Louisiana State University Medical Center recruited thirty women having had unfavourable biopsies. For twelve weeks, one third of these women received 200 mg of I3C; a second group got 400 mg; the remaining   women were given a placebo. The women’s 2OHE:16OHE ratios were tested to see what effect the I3C would have on their metabolism of estrogen. There was a dose-dependent increase in the ratio of “good” to bad” estrogens in the two  I3C groups, and no effect in the placebo group.